The Mesangial Cell Revisited: No Cell Is an Island

No man is an island.

No doctor is an island

No doctor is an island " expand the knowledge base of PH and the complexities of diagnosis and management of this group of patients " ; and lobbying power, " to create a force that will have levels of influence on many facets of PH management in Australia and New Zealand. " [3] (See the PHSANZ abstracts published in this issue of Pulmonary Circulation). they were joined by still more people in ...

No man is an island…

As much of my work is collaborative, I am very aware of the virtues and difficulties of collaboration in the modern scientific world. Most collaborations are short term; perhaps one scientist has an assay, the other a reagent, and an obvious quick gain will result from joining forces. But greater (though often less concrete) benefits come from longer term collaborations. Your collaborator may b...

Autophagy is involved in aldosterone-induced mesangial cell proliferation

The aim of the present study was to investigate whether autophagy is involved in aldosterone (Aldo)-induced mesangial cell (MC) proliferation. MCs were incubated with 10‑7 M Aldo for 24 h. Proliferation of MCs, and the underlying mechanisms, were subsequently analyzed using [3H]thymidine assay, cell counting assay, western blotting and RNA interference (RNAi). Aldo was revealed to induce autoph...

Antithrombin III Inhibits Mesangial Cell

Thrombin stimulates and heparin and heparan sulfate inhibit mesangial cell proliferation. In addition, heparin has been shown to inhibit thrombin-stimulated smooth muscle cell proliferation. The anticoagulant action of heparin is mediated by antithrombin Ill. This study investigated whether heparin’s antiproliferative action is also mediated by antithrombin Ill. To this end, the effect of antit...